Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Acetaminophen; Caffeine

Criteria

Inclusion criteria:

1. Women presenting to Maternal Evaluation Unit at UAB hospital

2. Confirmed live intrauterine pregnancy (previous ultrasound, bedside ultrasound, fetal monitoring)

3. Complaint of headache

4. Minimal pain level of 4 on VRS

Exclusion criteria:

1. Systolic BP >= 140 or diastolic BP>=90 with 1+ protein on urine dip

2. Systolic BP >=160 or diastolic BP>=105

3. Focal neurological symptoms

4. Altered level of consciousness defined as not being oriented to person, place, situation, and/or year

5. Complaint of seizure

6. Known under lying brain abnormality

7. Fever

8. Use of >3 grams of acetaminophen in past 24hrs

9. ONB in the past 3 months

10. Reported allergy to study medications (Bupivacaine, acetaminophen, or caffeine)