Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis

• Status: Unknown status
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Abundant evidence suggests that Angiotensin Converting Enzyme (ACE) inhibition potentially could reduce the hazardous effects of aortic stenosis and improve haemodynamics. The treatment seems safe even in patients with severe stenosis. There are however no randomised clinical trials that can confirm this hypothesis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Captopril; Trandolapril

Criteria

Inclusion Criteria:

• Valvular aortic stenosis with a aortic valve area < 1, 0 cm2

• Age > 18 years

• Willingness to give written informed consent

• For patients with symptomatic aortic stenosis at least one of following:

• Stable angina pectoris

• Syncope at exertion

• Dizziness at exertion

• Previous pulmonary oedema

• Patients in New York Heart Association functional class II-IV

Exclusion Criteria:

• Sitting systolic pressure < 100 mmHg

• Creatinine > 200 mM at screening

• Renal artery stenosis

• Pregnancy or planned pregnancy

• Participation in other studies

• Any patient characteristic that may interfere with compliance with the study protocol

• Treated with ACE-inhibitor or angiotensin receptor blocker within the last month

• Known allergy to ACE-inhibitors