Acute Effects of the Prostaglandin (Alprostadil) on Cerebral and Pulmonary Flow
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The second stage operation towards single ventricle palliation is 'bidirectional
cavopulmonary connection' (BCPC). The superior vena cava is connected to the pulmonary
artery, diverting 'blue' blood from the upper body (including the brain) to the lungs. A
successful BCPC requires sufficient and easy blood flow through the lungs. Alprostadil is the
synthetic form of prostaglandin (hormone that causes dilation of blood vessels) and has been
shown to increase blood flow in the brain hence increasing blood flow to the lungs after
BCPC, potentially useful in managing children post BCPC with low flow to the lungs and thus
poor oxygenation. This study propose to investigate acute effects of Alprostadil on different
blood vessels after BCPC.