Acute D2 Receptor Blockade Induced Neuronal Network Changes in Human Volunteers

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To detect the effect of second-generation antipsychotic drug on the neural activity.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Northwell Health
• Treatments: Risperidone

Criteria

Inclusion Criteria:

• Between 18 and 60 years of age

• Subject is competent to provide informed consent

Exclusion Criteria:

• Mini Mental Status Exam is less than 28

• Past or current history of any psychotic illness in the subject or in first degree family members

• Self report of illicit drug use (except marijuana) in the past. Use of marijuana during the last 3 month...

• Any use of antipsychotic in the past.

• Any neuro-anatomical lesions on previous brain imaging

• Any use of D2 receptor blocking agent (such as antiemetics) in the last two weeks.

• Any use of any psychotropic medications (SSRI, mood stabilizers, benzodiazepines, stimulants) in the last month.

• MRI contraindications

• Any cardiovascular or cerebrovascular diseases or conditions that predispose patients to hypotension (eg. dehydration, hypovolemia, antihypertensive medication)

• Subjects with diabetes mellitus, metabolic syndrome, hepatic or renal impairment, seizure disorder and any neurological disorder

• QTc interval longer than 450 ms for male and 470 ms for female

• Subjects who used any medications in the last two weeks (to avoid any possible drug-drug interactions)

• Pregnancy

• Individuals who are illiterate and/or visually impaired