Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Status:
Completed
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
Glucocorticosteroids recently have been shown to have non-genomic actions that are plasma
membrane-mediated and do not require gene transcription and translation. One of these
non-genomic effects is the inhibition of adrenergic agonist transport into airway vascular
smooth muscle cells with an increase of adrenergic agonist concentrations at adrenergic
receptor sites and enhance the physiological effects of endogenous adrenergic agonists (e.g.
locally released norepinephrine from noradrenergic neurons) or exogenous adrenergic agonists
(e.g. inhaled beta-adrenergic agonists).