Acupuncture or Metformin for Insulin Resistance in Women With PCOS
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
The hypothesis is that acupuncture is equally effective as metformin (both treatments
combined with lifestyle management) in improving whole body glucose homeostasis in insulin
resistant women with polycystic ovary syndrome (PCOS), and that both are superior to
lifestyle management alone. The investigators hypothesize that acupuncture and metformin
induce ovulation and improve hyperandrogenism, as well as health related quality of life
(HRQoL) and symptoms of anxiety and depression. Although equally effective (acupuncture and
metformin), the investigators hypothesize that acupuncture is associated with less negative
side-effects. The investigators also hypothesize that these treatments have the potential to
restore epigenetic and molecular alterations in target tissues (endometrial-, adipose-, and
skeletal muscle tissue) and thus have the potential to prevent the development of type 2
diabetes (T2D).