Activity and Metformin Intervention in Obese Adolescents
Status:
Completed
Trial end date:
2012-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to assess the sustainability of a two-year intervention aimed at
improving body mass index (BMI) and metabolic and vascular health in obese youth. The study
will compare lifestyle changes with diet and exercise alone with changes in lifestyle in
combination with metformin medication. An initial intensive exercise program will also be
compared with a standard exercise program.
Hypothesis: Metformin therapy in combination with intensive lifestyle intervention in obese
children and adolescents will be associated with reduced rate of weight gain, improved BMI,
body composition, physical activity, physical fitness, insulin sensitivity, blood lipid
profiles, adipocytokines and vascular function.