The purpose of this study is to evaluate changes in urine net acid excretion, blood pressure
and body chemistry that occur when the dietary acid load is lowered by using a drug/dietary
supplement similar to baking soda. This may be important for patients with kidney disease
because they may have difficulty removing all of the dietary acid load from the body in the
urine. Participants with and without kidney disease will be recruited. Each participant will
be fed a controlled diet for one week with sodium bicarbonate and for one week without sodium
bicarbonate to evaluate these changes. The investigators will also determine if the effect of
dietary acid load reduction is different in patients with kidney disease compared to those
without kidney disease.
Phase:
Phase 1
Details
Lead Sponsor:
Duke University
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)