Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure
Status:
Completed
Trial end date:
2017-10-01
Target enrollment:
Participant gender:
Summary
This study has two primary objectives:
1. To compare combination therapy with acetazolamide and low-dose loop diuretics versus
high-dose loop diuretics (standard of care) in patients with acute decompensated heart
failure at high risk for diuretic resistance.
2. To demonstrate the safety and efficacy of upfront therapy with spironolactone in
addition to loop diuretic therapy in patients with acute decompensated heart failure at
high risk for diuretic resistance.
Phase:
Phase 4
Details
Lead Sponsor:
Hasselt University
Collaborators:
Universitaire Ziekenhuizen Leuven University Hospital Leuven, Leuven, Belgium Ziekenhuis Oost-Limburg