Surgical procedures are routinely performed as an alternative to continuous positive airway
pressure treatment in patients with obstructive sleep apnea (OSA). However, the response to
surgery is often variable. Instability of the respiratory control during sleep (or high loop
gain) has been associated with poor surgical results in previous research. Acetazolamide
(AZM), a carbonic anhydrase inhibitor, has shown potential in reducing loop gain without
affecting other physiological OSA traits. In this protocol the investigators will evaluate
the clinical efficacy of AZM add-on therapy to surgical procedures in patients with OSA.