Acetaminophen Transfer Across the Placenta and the Assessment of Fetal Well-being

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study has two aims:

1. to evaluate placental transfer of acetaminophen from mother to baby transplacentally given from 30 minutes to 24 hours prior to cesarean delivery (34 patients)

2. to understand the impact of maternal acetaminophen use on fetal movement and breathing (20 patients)

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Acetaminophen

Criteria

Inclusion Criteria

• Pregnant females

• Age 18-44

• Any race

• Any parity

• Singleton Gestations

• Weight between 60-90 kg

Exclusion Criteria

• Acetaminophen Allergy

• Contraindication to Acetaminophen Use

• Chorioamnionitis

• Preeclampsia

• Diabetes Mellitus

• Placental Abruption

• Placenta Previa

• Fetal Anomaly

• Intrauterine growth restriction (IUGR)

• Multiple Gestations

• Maternal Medical Disease

• Acetaminophen use in the last 3 days

• Plan to donate or bank fetal cord blood