Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
Status:
Recruiting
Trial end date:
2023-08-31
Target enrollment:
Participant gender:
Summary
During menopause, there is a decrease in a hormone estrogen, which leads to aging of the
vagina. Vaginal aging includes changes in the type and amount of healthy bacteria in the
vagina, inflammation and a breakdown of natural barriers that keep the vagina healthy and
protected from infections. Some menopausal women develop a condition called vaginal atrophy,
which causes vaginal dryness, irritation, pain with sex, and itching. We are testing whether
an estradiol tablet placed inside the vagina will lead to fewer changes in the types of
bacteria present in the vagina, improve vaginal atrophy symptoms and ultimately keep the
vagina healthier for a longer. This is important for women with HIV as they are living
longer, healthier, sexually active lives due to successful treatment with antiretrovirals.
Phase:
Phase 4
Details
Lead Sponsor:
Albert Einstein College of Medicine
Collaborators:
National Institute on Aging (NIA) Novo Nordisk A/S