Accelerated Fractionation Radiotherapy (AFRT) Versus Concurrent Chemoradiotherapy (Crt) In Locally Advanced Head And Neck Squamous Cell Carcinoma

• Status: Unknown status
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this trial is to compare the accelerated fractionation radiotherapy and concurrent chemo-radiotherapy in locally advanced head and neck squamous cell carcinoma patients in terms of loco-regional control, toxicities and quality of life.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: All India Institute of Medical Sciences, New Delhi
• Treatments: Cisplatin

Criteria

Inclusion Criteria:

1. Age: 20 - 60 years old

2. Karnofsky performance scale score 70 or above

3. Biopsy proven squamous cell carcinomas (SCC) of oropharynx, larynx and hypopharynx

4. TNM stages- Stage III -IVB

5. Informed consent (in prescribed form under institutional guidelines)

Exclusion Criteria:

1. Lack of histopathological proof of malignancy (HNSCC)

2. Doubtful follow-up and/ or non-compliance

3. Previous oncologic therapy with surgery, radiotherapy or chemotherapy

4. Uncontrolled comorbid conditions e.g hypertension, diabetes mellitus, chronic obstructive pulmonary disease, coronary artery disease