Acarbose and Secondary Prevention After Coronary Stenting

• Status: Completed
• Trial end date: 2009-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the intervention for newly diagnosed abnormal glucose tolerance after coronary stenting will improve the long-term clinical outcome.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan; Translational Research Informatics Center, Kobe, Hyogo, Japan
• Collaborators: Institute of Biomedical Research and Innovation, Kobe, Hyogo, Japan; Kobe City General Hospital
• Treatments: Acarbose

Criteria

Inclusion Criteria:

• Within 8 weeks since implantation of coronary artery stents for stable angina pectoris or acute coronary syndrome.

• Abnormal glucose tolerance according to a 75 g oral glucose tolerance test (OGTT).

• HbA1c is less than 6.5%.

• Age is between 20 and 75 years (at time of consent).

• Patients who can give informed consent themselves in writing.

Exclusion Criteria:

• Patients with abnormal glucose tolerance caused by other organic disorders such as pancreatitis, hemochromatosis, post pancreatectomy, hyperthyroidism, Cushing syndrome, Prader-Willi syndrome, etc.

• Patients with planned angioplasty.

• Patients with uncontrollable congestive heart failure.

• Less than 6 months since last episode of cerebral infarction.

• Patients who have received medication for diabetes mellitus before.

• AST (GOT) exceeding 100 IU/L or ALT (GPT) exceeding 100 IU/L.

• Creatinine exceeding 2 mg/dl.

• Patients with a history of ileus or less than 6 months since celiotomy.

• Pregnant women or those who plan to become pregnant, or are in the lactation period.

• Habitual drinker (more than 100 ml/day of alcohol).

• Patients with a history of gastrectomy.

• Patients for whom it is impossible to follow up for 5 years.

• Any other reason that the clinical supervisors or clinical researchers may have for considering a case unsuitable for the study.