Acarbose and Older Adults With Postprandial Hypotension

• Status: Completed
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The current proposal will determine if blocking carbohydrate intake in the small intestine with Acarbose can be a possible therapy for older adults with (PPH) Post Prandial Hypotension (a drop of blood pressure after eating), which can result in falls.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kenneth Madden; University of British Columbia
• Treatments: Acarbose; Glycoside Hydrolase Inhibitors

Criteria

Inclusion Criteria:

• be 65 years of age or older,

• be a non-smoker for at least 5 years

• be referred to the falls clinic at Vancouver General Hospital

• have a Folstein test of cognition > 25/30 to ensure meal log-book compliance

Exclusion Criteria:

• no oral or swallowing issues that would prevent a Meal Test

• subject requiring dialysis due to end-stage renal failure will be excluded

• subjects with evidence on history, physical or blood work of hepatic disease will be excluded since elevated serum transaminases are a potential adverse effect of acarbose

• cannot currently be taking an alpha-glucosidase inhibitor

• cannot have had allergic reactions to alpha-glucosidase inhibitors in the past

• Due to the fact that acarbose is renally excreted, all subjects must have a Creatine Clearance of greater than 25 ml/min

• Subjects with a past history of inflammatory bowel disease, intestinal obstruction, ileus and peptic ulcer disease will be excluded

• Subjects taking carbohydrate-splitting enzymes (such as amylase) will be excluded

• Subjects with chronic respiratory issues requiring treatment will be excluded