Abrupt Versus Tapered Interruption of Chronic Clopidogrel Therapy After DES Implantation

• Status: Terminated
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis to be tested is that gradual clopidogrel therapy cessation is associated with a superior clinical outcome compared with abrupt cessation (superiority hypothesis).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Deutsches Herzzentrum Muenchen
• Treatments: Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• Patients with planned interruption of chronic clopidogrel therapy after DES implantation

• Informed, written consent by the patient

Exclusion Criteria:

• Planned surgery within the next month

• Active bleeding as reason for clopidogrel discontinuation

• Concomitant coumadin therapy

• Pregnancy (present, suspected or planned) or positive pregnancy test (In women with childbearing potential a negative pregnancy test is mandatory)

• Malignancies or other comorbid conditions with a life expectancy of less than one year or that may result in protocol noncompliance.

• Patient's inability to fully comply with the study protocol.