Abiraterone and Prednisone or Darolutamide for the Treatment of Advanced Prostate Cancer
Status:
Recruiting
Trial end date:
2027-05-01
Target enrollment:
Participant gender:
Summary
This phase II trial compares the effects, good and/or bad of abiraterone and prednisone or
darolutamide alone in treating patients with prostate cancer that may have spread from where
it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced).
Androgens (male hormones) can cause the growth of prostate tumor cells. Abiraterone acetate
lowers the amount of androgens made by the body. This may help stop the growth of prostate
tumor cells that need androgen to grow. Darolutamide blocks the use of androgens by the tumor
cells. Prednisone is used to lessen inflammation and lower the body's immune response.
Researchers want to compare the side effects of standard of care (SOC) abiraterone and
prednisone or darolutamide alone in treating patients with advanced prostate cancer.