The purpose of this study is to investigate the pharmacokinetic properties in critically ill
patients of a few of the most used antimicrobial drugs (amikacin, linezolid, meropenem,
piperacillin/tazobactam, vancomycin). The primary objective is the identification of the
clinical parameters affecting the kinetics of these drugs and the study of the contribution
of extracorporeal depuration techniques to the elimination of these molecules. The secondary
objective is to describe and compare the therapeutic therapies adopted in the Intensive Care
Units participating in the project.
For each molecule, the study will involve 300 patients admitted to Intensive Care Units. For
each patient five blood samples will be collected on average, in order to measure drug plasma
concentrations. Patient clinical conditions will be collected through an electronic clinical
record. Finally, on the basis of those data, pharmacokinetic models will be developed to
describe the evolution in time of drug plasma concentrations.
Details
Lead Sponsor:
Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva