Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
The primary objective of this research study is to test the hypothesis that late sodium
current blocking drugs (mexiletine or lidocaine) can attenuate the effect of hERG potassium
channel blocking drugs (dofetilide) on ventricular repolarization (QTc) by shortening early
repolarization (J-Tpeakc). The secondary object is to assess the ability of calcium channel
block (diltiazem) to reduce the QTc prolongation associated with hERG block (moxifloxacin).