Ability of Curcumin to Decrease Cytokines Involved in Mucositis in the Autologous Transplant
Status:
Completed
Trial end date:
2015-07-03
Target enrollment:
Participant gender:
Summary
Mucositis is a very common complication in bone marrow transplant setting. It is a result of
injury to the gut caused by high dose chemotherapy. Currently there are no universal
protocols that have been accepted as a standard to prevent and treat mucositis in the
transplant setting. Post transplant upto 80% of patients suffer from a severe mucositis.
Proinflammatory cytokines play a major role in the development of mucositis. Interventions
that decrease the levels of these cytokines may be beneficial in preventing mucositis. This
study is aimed at evaluating the role of curcumin in reducing cytokine levels and the
incidence and duration of mucositis in patients undergoing autologous stem cell
transplantation.