Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers

• Status: Unknown status
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to determine whether aprepitant blocks the opiate reward system in non-dependent opiate abusers, indicating its potential as a safe, non-addictive first line therapy for early heroin abuse.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karolinska University Hospital
• Collaborators: County of Stockholm; Ministry of Health and Social Affairs, Sweden
• Treatments: Aprepitant; Buprenorphine; Fosaprepitant

Criteria

Inclusion Criteria:

• Age 18 - 50

• Current opiate use, without dependence

Exclusion Criteria:

• Clinical diagnosis of opiate dependence

• Positive urine screen for opiates on day of challenge sessions

• Meet diagnostic criteria for any other substance abuse disorder except nicotine within the last 12 months.

• Any ongoing prescription medication other than oral contraceptives or hormone replacement

• Any serious medical condition which in the judgment of the investigators makes administration of opiates medically inappropriate.