Overview

Abatacept Reversing Subclinical Inflammation as Measured by MRI in ACPA Positive Arthralgia

Status:
Completed
Trial end date:
2019-12-01
Target enrollment:
0
Participant gender:
All
Summary
This is a randomised double-blinded placebo-controlled multi centre study in 98 patients with ACPA positive arthralgia. The study is composed of 2 arms with a 1:1 randomisation at baseline: Treatment phase will be 6 months. Group 1: Abatacept s.c. 125 mg weekly for 6 months vs. Group 2: Placebo s.c. for 6 months. After 6 months both groups will run into the follow up period for another 12 months up to month 18. Patients developing arthritis will be treated according to local guidelines.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Collaborator:
Bristol-Myers Squibb
Treatments:
Abatacept
Criteria
Inclusion Criteria:

- Females and males aged ≥ 18 years at time of consent

- ACPA (with or without RF)

- Joint pain (hand, feet, knee, shoulder or elbow) present for at least 6 weeks prior to
inclusion or in past history

- Presence of synovitis (synovialitis or tenosynovitis) or osteitis in MRI of the
dominant hand at baseline

- Women of childbearing potential or men capable of fathering children must be using
effective contraception during treatment with abatacept and up to 14 weeks after the
last dose of abatacept treatment.

- Must understand and voluntarily sign an informed consent form including written
consent for data protection

- Must be able to adhere to the study visit schedule and other protocol requirements

Exclusion Criteria:

- Presence of arthritis in hand, feet, knee, shoulder or elbow joints defined as
swelling

- Current treatment with glucocorticoids conventional or biologic DMARDs

- Previous treatment with abatacept

- Investigational study drug within 4 weeks (or 5 half lives, whichever is longer) prior
to randomization

- Any condition, including the presence of laboratory abnormalities, which places the
subject at unacceptable risk if he/she were to participate in the study or confounds
the ability to interpret data from the study

- Any other autoimmune or inflammatory disease such as SLE, PSS, MCTD, SpA, Behcet
disease, vasculitis or autoimmune hepatitis.

- Any malignancy in the last 5 years

- Chronic infection such as latent TB (TB not adequately treated according to
guidelines) or hepatitis B or C infection

- Immunocompromised or HIV-positive patients

- Uncontrolled severe concomitant disease

- Patients who are younger than 18 years or are incapable to understand the aim,
importance and consequences of the study and to give legal informed consent (according
to § 40 Abs. 4 and § 41 Abs. 2 and Abs. 3 AMG).

- Pregnant or lactating females

- Patients who possibly are dependent on the Principal Investigator or Investigator
(e.g. family members).