Background:
- AZD7451 is a drug that may help interfere with brain tumor cell growth. It can prevent
glioma cells from entering into normal brain tissue, and slow or stop the growth of
additional tumors. Researchers want to see if AZD7451 is effective against gliomas that have
not responded to surgery, radiation, or chemotherapy.
Objectives:
- To see if AZD7451 is a safe and effective treatment for gliomas that have not responded to
standard treatments.
Eligibility:
- Individuals at least 18 years of age who have gliomas that have not responded to standard
treatments.
Design:
- Participants will be screened with a physical exam, medical history, blood and urine
tests, heart function tests, an eye exam, and imaging studies.
- Participants will take AZD7451 daily by mouth for 28-day cycles of treatment.
- Participants will keep a medication diary and record any side effects. Treatment will be
monitored with frequent blood tests and imaging studies.
- Treatment will continue as long as there are no serious side effects and the tumor does
not start growing again....