AZ, MZ, and the Pulmonary System Response to Hypoxia
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this proposal is to compare the physiological effects of acetazolamide (AZ)
and methazolamide (MZ) on the control of breathing and hypoxic pulmonary vasoconstriction.
The first objective is to assess the effects of AZ and MZ on the control of breathing in
normoxia and hypoxia. To achieve this the ventilatory interaction between oxygen and carbon
dioxide will be measured and effects compared between placebo, AZ, and MZ conditions. In
addition, the isocapnic and poikilocapnic hypoxic ventilatory response and hypercapnic
ventilatory response will be measured with each drug. The second objective is to assess the
effects of AZ and MZ on the control of the pulmonary vasculature during hypoxia. Pulmonary
pressure and cardiac output will be measured during 60 minutes of poikilocapnic hypoxia.