AWARE: Management of ADHD in Autism Spectrum Disorder
Status:
RECRUITING
Trial end date:
2027-12-30
Target enrollment:
Participant gender:
Summary
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists. Findings from this study will help improve clinicians' approach to medication selection and reduce the repeated trials of multiple medications that are current standard care.
Phase:
PHASE4
Details
Lead Sponsor:
Daniel Coury
Collaborators:
Children's Hospital Los Angeles Children's Hospital Medical Center, Cincinnati Children's Hospital of Philadelphia Holland Bloorview Kids Rehabilitation Hospital MaineHealth Massachusetts General Hospital Nationwide Children's Hospital Patient-Centered Outcomes Research Institute University of Alberta University of California, Irvine University of Michigan University of Pittsburgh University of Rochester University of Virginia