Approximately 90 male and female patients with documented solid tumor malignancies of
epithelial origin that are locally advanced or metastatic, and either refractory to standard
therapy or for whom no standard therapy is available, will be entered into this Phase 1a/2a,
multicenter, open-label, dose-escalation, cohort study of AVID100. Phase 2a will include
evaluation of patient with EGFR-overexpressing squamous histology non-small cell lung cancer,
squamous cell carcinoma of the head and neck, and triple negative breast cancer