AVANDIA With Glyburide In African American And Hispanic Patients With Type 2 Diabetes Not Controlled by Glyburide Alone
Status:
Completed
Trial end date:
2003-01-06
Target enrollment:
Participant gender:
Summary
This study was designed to evaluate the safety and efficacy of AVANDIA (rosiglitazone) (8mg
once daily) in African American and Hispanic patients with type 2 diabetes mellitus. As
microvascular and macrovascular disease are significant contributors to diabetes morbidity
and mortality and previous studies suggest that the thiazolidinedione compounds could have
potentially beneficial vascular effects, the effects of rosiglitazone therapy on serum
parameters associated with endothelial dysfunction, vascular inflammation and impaired
fibrinolysis were examined in this study. Improvement in these parameters suggests that
rosiglitazone may provide an additional beneficial vascular effect, apart from its ability to
improve glycemic control.