AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation

• Status: Not yet recruiting
• Trial end date: 2029-03-31
• Target enrollment: 0
• Participant gender: All

Summary

A study comparing atrioventricular junction ablation (AVJA) versus continued optimum medical rate control in patients with cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) with suboptimal heart rate control on optimum medication.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Ostrava

Criteria

Inclusion Criteria:

• Treatment with CRT using either a biventricular pacemaker/defibrillator or conduction system pacemaker (>6 months)

• Diagnosis of AF and classified as: permanent AF or recurrent persistent AF, requiring emergency visits and/or hospitalizations (at least one in recent year)

• Optimized HF medical treatment and rate control medication

• BiVP% + ventricular premature complex (VPC%) <99% and >85% during the minimum period of 1 month while already on optimum medical therapy (applicable only for patients with permanent AF)

• Age >18 and <85 years

• Signed informed consent

Exclusion Criteria:

• myocardial infarction (MI) or coronary artery bypass graft (CABG) <3 months

• Technical failure of the CRT system

• Intentional preference for spontaneous AV conduction

• Expected survival <1 year

• Other significant comorbidities and/or conditions that interfere with the proper conduction of the trial

• Dementia as assessed by mini-mental test (<23 points)