In clinical practice, amoxicillin + clavulanic acid is widely used in the treatment of
odontogenic infection. Therefore, this study is designed to generate data to support its use
by demonstrating efficacy, safety and tolerability in comparison with clindamycin in subjects
with acute odontogenic infections with or without abscess. This will be a two-arm, parallel,
comparative, observer blind, randomised study to assess efficacy, safety and tolerability of
amoxicillin + clavulanic acid (875mg/125mg) in comparison with clindamycin (150mg)
administered for 5-7 days in subjects with acute odontogenic infections with or without
abscess. The study will be performed in adult subjects both male and female ≥18 years of age
who present with acute odontogenic infections. A total of 472 subjects will be randomized in
1:1 ratio, i.e. 236 subjects in each treatment arm. The treatment duration of the study will
be at least 5 days or maximum 7 days depending upon the treatment response. Subjects will be
assessed on Day 5 and if Investigator feels the need of continuing the treatment at Day 5
then treatment will be continued till Day 7. For subjects who do not show treatment response
on Day 5, assessments will be performed on Day 7.