Overview

ATORvastatin in Pulmonary TUBerculosis: a PharmacoKinetics Sub-study

Status:
NOT_YET_RECRUITING
Trial end date:
2027-09-30
Target enrollment:
Participant gender:
Summary
The purpose of this study is to assess pharmacokinetic parameters of atorvastatin at different doses when combined with the standard tuberculosis (TB) treatment regimen in adults with pulmonary TB. The pharmacokinetics parameters will be correlated with Pharmcodynamic measures and a PK/PD model that will identify an optimal dosing regimen of atorvastatin that is appropriate for the treatment of pulmonary tuberculosis will be developed.
Phase:
PHASE2
Details
Lead Sponsor:
Obafemi Awolowo University Teaching Hospital
Collaborators:
Obafemi Awolowo University
Open Philanthropy
Treatments:
Atorvastatin
Ethambutol
Isoniazid
Protons
Pyrazinamide