Background:
- The experimental drug AT13387 has been shown to have some anticancer effects against tumor
cells by blocking a protein that affects other proteins inside certain cancer cells, and
helps to prevent the cancer cells from reproducing and spreading. AT13387 has not been tested
in humans, and researchers are interested in investigating whether it can be used to treat
solid tumors that have not responded to standard treatments.
Objectives:
- To investigate the safety and effectiveness of AT13387 in individuals with solid tumors.
Eligibility:
- Individuals at least 18 years of age who have solid tumors that have not responded to
standard treatments.
Design:
- Participants will be screened with a physical examination and medical history, as well
as blood tests and tumor imaging studies.
- AT13387 will be given in 28-day cycles of treatment. Participants will receive AT13387
twice a week (2 days in a row) for the first 3 weeks of the cycle, followed by a fourth
week without the drug.
- Participants will have regular blood and urine samples, imaging studies, eye
examinations, and tumor biopsies to monitor the effects of the treatment.
- Participants will continue treatment with AT13387 unless serious side effects develop or
the tumor stops responding to treatment.