ANGIOCOMB Antiangiogenic Therapy for Pediatric Patients With Diffuse Brain Stem and Thalamic Tumors

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether initial local irradiation with topotecan and following oral antiangiogenic drugs, thalidomide, celecoxib and etoposide are effective in the treatment of pediatric diffuse brainstem tumor.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University Central Hospital
• Collaborators: Kuopio University Hospital; Oulu University Hospital; Tampere University Hospital; Turku University Hospital
• Treatments: Angiogenesis Inhibitors; Celecoxib; Etoposide; Etoposide phosphate; Thalidomide

Criteria

Inclusion Criteria:

-pediatric diffuse brainstem tumor

Exclusion Criteria:

• wish of the family

• need for strong painrelievers

• decreased level of consciousness

• inability to swallow.