ANG1005 in Patients With Recurrent High-Grade Glioma

• Status: Completed
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a Phase 2 study to see if an investigational drug, ANG1005, can shrink tumor cells in patients with high-grade glioma. Another purpose of this study is to assess the efficacy, safety, tolerability, and pharmacokinetics (PK) of ANG1005 in patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Angiochem Inc
• Treatments: Bevacizumab; Paclitaxel

Criteria

Inclusion Criteria:

1. ≥ 18 years old

2. GBM and GBM variants, WHO Grade III anaplastic glioma diagnosis confirmed

3. Radiologically confirmed recurrent and bi-dimensionally measurable disease per Response Assessment in Neuro-Oncology (RANO) criteria

4. Neurologically stable

5. For bevacizumab-refractory patients, radiologic demonstration of tumor progression during bevacizumab therapy

6. Karnofsky performance status (KPS) ≥ 80

7. Expected survival of at least 3 months

Exclusion Criteria:

1. More than three relapses

2. Previous ANG1005/GRN1005 treatment

3. Radiotherapy within 3 months.

4. Therapy with bevacizumab within 4 weeks prior to Day 1 of treatment for recurrent WHO grade III anaplastic glioma patients (Arm 3)

5. Evidence of significant intracranial hemorrhage

6. Previous taxane treatment

7. Prior therapy with bevacizumab for bevacizumab-naïve patients (Arm 1)

8. NCI Common Toxicity Criteria for Adverse Effects (CTCAE) v4.0 Grade ≥ 2 neuropathy

9. Inadequate bone marrow reserve

10. Any evidence of severe or uncontrolled diseases

11. Participants with the presence of an infection including abscess or fistulae, or known infection with hepatitis C or B or HIV

12. Known severe hypersensitivity or allergy to paclitaxel or any of its components