Adenosine monophosphate (AMP) may reflect airway inflammation and hyperresponsiveness, but
relationship between AMP and histamine (His, a conventional stimulus) bronchial provocation
test (BPT) in asthma is not fully elucidated.
The investigators aimed to compare both BPTs and determine their usefulness in reflecting
changes of asthmatic symptoms.
BPTs were performed in cross-over fashion, at 2-4day intervals. Cumulative doses eliciting
20% FEV1fall (PD20FEV1), diagnostic performance and adverse events were compared. Patients
with PD20FEV1 lower than geometric mean were defined as responders, otherwise poor
responders. Patients with uncontrolled and partly controlled asthma, who maintained their
original inhaled corticosteroids therapy, underwent reassessment of airway responsiveness and
asthmatic symptoms 3 and 6 months after.
Phase:
N/A
Details
Lead Sponsor:
Guangzhou Institute of Respiratory Disease
Treatments:
Adenosine Budesonide Fluticasone Fluticasone Propionate, Salmeterol Xinafoate Drug Combination Fluticasone-Salmeterol Drug Combination Histamine Salmeterol Xinafoate