ALL-SCT BFM International- HSCT in Children and Adolescents With ALL
Status:
Unknown status
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
With this protocol the ALL-SCT BFM international study group wants
- to evaluate whether hematopoietic stem cell transplantation (HSCT) from matched family
or unrelated donors (MD) is equivalent to the HSCT from matched sibling donors (MSD).
- to evaluate the efficacy of hematopoietic stem cell transplantation (HSCT)from
mismatched family or unrelated donors (MMD) as compared to HSCT from matched sibling
donors or matched donors.
- to determine whether therapy has been carried out according to the main HSCT protocol
recommendations. The standardisation of the treatment options during HSCT from different
donor types aims at the achievement of an optimal comparison of survival after HSCT with
survival after chemotherapy only.
- to prospectively evaluate and compare the incidence of acute and chronic
Graft-versus-Host-Disease (GvHD) after HSCT from matched sibling donor (MSD), from
matched donor (MD) and from mismatched donor (MMD).