Aldehyde dehydrogenase (ALDH) enzyme supplementation plays an essential role in the
elimination of toxic metabolites and reduction of reactive oxygen species bioactivation,
which can protect and relieve chemotherapy-related fatigue (CRF) in cancer patients. The aim
of this study is to evaluate the efficacy and safety of ALDH enzyme in CRF with advanced
gastrointestinal cancer patients. The primary endpoint is the change of FACIT-F (Functional
Assessment of Chronic Illness Therapy-Fatigue) score on day 15 compared to baseline after
chemotherapy. The secondary endpoint including change of FACIT-F on day 29 compared to day
15, change of ESAS (Edmonton Symptom Assessment System) on day 15 compared to baseline,
safety and toxicities, and exploratory biomarkers.