This study will examine the gene expression of the adrenergic Beta-3 receptor (ADRB3)
regulation in human subcutaneous adipose tissue before and after treatment with mirabegron,
an ADRB3 agonist. Gene expression will be compared across two groups, lean and obese
participants. There will be a total of three study visits: Screening/Eligibility, Pre-Dose
Adipose Tissue Biopsy and Post-Dose Adipose Tissue Biopsy. Participants will be given a
single dose of 100mg oral mirabegron on the day of the Post-Dose Adipose Tissue Biopsy.The
trial design is a single-center, phase 1, open-label, exploratory study to examine the
adipocyte gene expression in adults treated with 1 dose of 100mg oral mirabegron.