Overview

ADMIRAL Trial: Adaptive Mediastinal Radiation With Chemo-Immunotherapy

Status:
Recruiting
Trial end date:
2026-11-30
Target enrollment:
Participant gender:
Summary
This phase II trial studies two questions in patients with stage III NSCLC: 1) does it improve cancer control to add the drug Durvalumab, a type of immunotherapy, earlier in the treatment course; and 2) by intensifying treatment with durvalumab, is it possible to avoid mediastinal radiation to decrease side effects, without decreasing cancer control?
Phase:
Phase 2
Details
Lead Sponsor:
University of Washington
Collaborators:
AstraZeneca
National Cancer Institute (NCI)
Treatments:
Antibodies, Monoclonal
Cisplatin
Durvalumab
Etoposide
Etoposide phosphate
Immunoglobulin G
Immunoglobulins
Pemetrexed
Podophyllotoxin