ABT-335 (Choline Fenofibrate) Reverse Cholesterol Transport (RCT) Study

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The objectives of the study are:

1. To evaluate the effect of ABT-335 (choline fenofibrate) on several parameters of RCT (reverse cholesterol transport) in men and post-menopausal women diagnosed with dyslipidemia (i.e., low high-density lipoprotein [HDL] cholesterol levels and elevated triglyceride [TG] concentrations).

2. To evaluate longitudinal changes in several parameters of RCT in subjects with low HDL.

3. To obtain pilot data for power calculations for subsequent comparative study.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Radiant Research
• Treatments: Choline; Fenofibrate

Criteria

Inclusion Criteria:

1. Male, non-smoker, 21 - 75 years of age inclusive.

2. Female, non-smoker, 40 - 75 years of age inclusive.

3. Post-menopausal women, as defined by lack of menses for at least 2 years and age > 55, OR history of documented bilateral surgical oophorectomy, confirmed with an elevated follicle-stimulating hormone (FSH) at screening.

4. HDL concentration (≤ 50 mg/dl women, ≤ 40mg/dl men)

5. TG concentration 150-500 mg/dl, inclusive

6. Ability to give informed consent

Exclusion Criteria:

1. Subject has history of diabetes mellitus, active hepatitis, gall bladder disease, gastric bypass surgery, or clinically significant abnormalities on screening (prestudy) physical examination or laboratory tests.

2. Screening laboratory tests with hematocrit <30%, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2X upper limit of normal, abnormal thyroid-stimulating hormone (TSH), fasting glucose ≥126 mg/dl.

3. Renal impairment with creatinine clearance < 80 ml/min.

4. Treatment within the last 6 months with drugs known to alter lipid metabolism including beta blockers, thiazide diuretics, bile acid resins, ezetimibe, fibrates, niacin, and fish oils (see Appendix 1). Washout of fibrates is not permitted.

5. Treatment with drugs known to interact with ABT-335, e.g., warfarin (see Appendix 1).

6. Treatment with HMG CoA reductase inhibitors (statins) within the past 4 weeks (see Appendix 1).

7. History of allergy to egg or soy products.

8. History of coronary heart disease (CHD), stroke or revascularization procedure in the six months prior to Visit 1.

9. Current or recent history (past 12 months) of drug abuse or alcohol abuse. Alcohol abuse will be defined as >14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or 1.5 oz hard liquor).

10. Participation in another clinical trial or exposure to any investigational agent within 30 days before visit 1.

11. Individual has a condition the Principal Investigator believes would interfere with his/her ability to provide informed consent, comply with study instructions, or which might confound the interpretation of the study results or put the subject at undue risk.