A Two-Step Approach to Bone Marrow Transplant Using Cells From A Partially-Matched Relative
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to develop a way of treating patients who do not have a
completely matched family donor or a readily available unrelated donor with bone marrow
transplant by using a partially-matched family donor. Patients receiving this type of
transplant will receive chemotherapy and/or radiation to treat their disease. They will also
receive their donor's cells in 2 parts. During the first part, the donor's lymphocytes will
be exposed to one of the chemotherapy agents to help the patient become tolerant to the
lymphocytes. In the second part of the transplant, the patient will receive their donor's
stem cells to help recover their peripheral blood counts and establish long-term engraftment.
The hypothesis of this study is that in partially-matched allogeneic transplant, there is a
defined number of donor T-cells that can be treated and given to the recipient to avoid
post-transplant infection without causing severe graft-versus-host disease.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University