A Trial to Evaluate the Effect of Itraconazole (ITZ), a CYP3A4 Inhibitor, on the Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator, Olinciguat (IW-1701), in Healthy Volunteers

Status:
Completed

Trial end date:
2019-07-03

Target enrollment:

Participant gender:

To evaluate the effect of itraconazole (a potent cytochrome P450 isoenzyme [CYP]3A inhibitor) on the pharmacokinetics (PK) of olinciguat

Phase 1

Cyclerion Therapeutics
Ironwood Pharmaceuticals, Inc.

Hydroxyitraconazole
Itraconazole