A Trial to Evaluate Epothilone D in Patients With Advanced Solid Tumors
Status:
Completed
Trial end date:
2003-06-01
Target enrollment:
Participant gender:
Summary
Epothilone D represents one of a class of cytotoxic macrolides capable of causing mitotic
arrest by stabilizing tubulin polymerization. Since microtubules are essential for mitosis,
motility, secretion and proliferation, the observed antitumor effects of epothilones have
been attributed to their ability to initiate cell death by inhibiting such processes.
Epothilone D has demonstrated in vitro cytotoxic activity in a panel of human cell lines,
equipotent to that of paclitaxel. In vivo, Epothilone D has also shown significant antitumor
activity in a range of xenograft models, including paclitaxel-resistant xenografts.
Epothilone D is more potent than paclitaxel in cell lines that demonstrate multiple drug
resistant activity overexpressing p-glycoprotein.