A Trial on Conservative Treatment for Infants' Hirschsprung Disease

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in infants with short or normal-segment Hirschsprung disease.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tongji Hospital

Criteria

Inclusion Criteria:

• Hard or firm stools for twice or less per week

• Age were from newborn to 3 months

• Histochemical acetylcholinesterase reaction (AChE) in rectal mucosa was positive

• The narrowed distal bowel on barium enema was characterized as normal or short-segment Hirschsprung disease with a 24h barium retention

Exclusion Criteria:

• Children >3months of age

• Patients presented severe inflammation or malnutrition, unconsciousness, and symptoms of a ruptured hollow viscus

• Barium enema showed long-segment or total colonic aganglionic bowel