A Trial of the Combined Impact of Intermittent Preventive Treatment and Insecticide Treated Bednets in Reducing Morbidity From Malaria in African Children

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

An investigation will be made of the combined impact of insecticide-treated nets and intermittent preventive treatment with amodiaquine + sulfadoxine-pyrimethamine on malaria morbidity in children in Burkina Faso and Mali.Three rounds of treatment will be given during the malaria season in one year and the follow-up will be extended into the second year by passive surveillance.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: London School of Hygiene and Tropical Medicine
• Collaborators: Centre national de recherche et de formation sur le paludisme; Malaria Research and Training Centre, Mali
• Treatments: Pyrimethamine

Criteria

Inclusion Criteria:

• Permanent residence in the study area with no intention of leaving during the surveillance period.

• Obtention of informed consent.

Exclusion Criteria:

• Temporary residence in the study area.

• Absence of informed consent.

• Presence of a severe, chronic illness such as severe malnutrition (Kwashiorkor or marasmus) or AIDS, likely to interfere with evaluation of the trial results.

• A history of a previous, significant adverse reaction to either of the study drugs.