A significant number of patients with Parkinson's disease (PD) face motor fluctuations even
after repeated titration of the dosing of Levodopa. Dealing with OFF state really becomes
problematic for them. Aggravation of bradykinesia, rigidity, tremor and gait difficulty are
the common problems in OFF state. Studies are going on drugs like Apomorphine as rescue
therapy in OFF state. Recently there are studies with Noninvasive brain stimulation, as an
evolving therapeutic option in different neurodegenerative diseases. In this study, the
investigators are to evaluate the efficacy of transcranial pulsed current stimulation (tPCS)
in the OFF state in PD patients. The investigators will give stimulation via tPCS
(active/sham). EEG, Kinematic measurement of upper limb movement via KinArm, Unified
Parkinson's Disease Rating Scale (UPDRS) scoring will be done and gait will be assessed via
Gait Carpet - pre and post-stimulation. The investigators will evaluate the effectiveness of
tPCS as a single modality or in combination with Levodopa in managing OFF state of PD.