A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma

• Status: Completed
• Trial end date: 2020-05-31

Summary

This is a phase I study of temsirolimus (Torisel) combined with dexamethasone, cyclophosphamide and etoposide in patients with relapsed acute lymphoblastic leukemia (ALL), lymphoblastic lymphoma (LL) or peripheral T-cell lymphoma (PTL).

• Phase: Phase 1

Details

• Lead Sponsor: Therapeutic Advances in Childhood Leukemia Consortium
• Collaborator: Pfizer
• Treatments: Cortisol succinate; Cyclophosphamide; Cytarabine; Etoposide; Etoposide phosphate; Everolimus; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate; Methotrexate; Sirolimus