A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma
Status:
Active, not recruiting
Trial end date:
2028-05-01
Target enrollment:
Participant gender:
Summary
The primary purpose of this study is to investigate whether surgery and re-irradiation will
help treat ependymoma that has come back after initial treatment. The combined doses of the
first and second courses of radiation are higher than what is usual standard of care. The
investigators will study the effects and side effects of surgery and re-irradiation. They
will also evaluate and study tumor tissue and blood to learn more about the tumor and how it
does or does not respond to treatments and will use magnetic resonance imaging (MRI) and
positron emission tomography (PET) scans to see if they can predict tumor response and tumor
recurrence.
Participants will be followed for up to 5 years following enrollment. Evaluations during
radiation therapy will be done weekly while receiving therapy for up to 7 weeks. Other
evaluations will be done at enrollment, every 4 months from enrollment through 3 years, and
every 6 months during the 4th and 5th year.