A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With Metastatic Colorectal Cancer
Status:
Terminated
Trial end date:
2016-09-06
Target enrollment:
Participant gender:
Summary
This phase II trial studies how well capecitabine and celecoxib with or without radiation
therapy works in treating patients with colorectal cancer that is newly diagnosed or has been
previously treated with fluorouracil, and has spread to other parts of the body (metastatic).
Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth
of tumor cells, either by killing the cells or by stopping them from dividing. Celecoxib may
stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Radiation therapy uses high-energy x-rays to kill tumor cells. Giving capecitabine and
celecoxib together with radiation therapy may kill more tumor cells.