A Trial Comparing the Efficacy and Safety of Open Dressing With Petrolatum Jelly vs. Standard Gauze Dressing With Silver Sulfadiazine

• Status: Completed
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The Effectiveness of open dressing with petrolatum jelly in minor burns has not been clearly established. This study determined if the use of open dressings with petrolatum jelly as effective as standard gauze dressing with silver sulfadiazine in treating minor burns in terms of time-to-re-epithelialization, incidence of wound infection,incidence of adverse reactions, and patient acceptance.

Non-extensive superficial partial thickness burns constitute a major proportion of burn injuries. Conventional treatment involves regular changing of absorptive dressings including the application of a topical antimicrobial, commonly silver sulfadiazine. A systematic review has found insufficient evidence to support or refute such antimicrobial prophylaxis. Another review compared silver sulfadiazine dressings with other occlusive and non-antimicrobial dressings and found insufficient evidence to guide practice. Other research has suggested that dressings with petrolatum gel are as effective as silver sulfadiazine. This trial sought to compare the effectiveness of conventional silver sulfadiazine dressings with treatment with petrolatum gel alone.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of the Philippines
• Collaborator: Committee on Research Implementation and Development
• Treatments: Petrolatum; Silver Sulfadiazine; Sulfadiazine

Criteria

Inclusion Criteria:

• Patients aged 18-45 years old

• Superficial partial thickness burns less than or equal to 10% Total Body Surface Area

Exclusion Criteria:

• Patients with burns involving the primary areas (face, hand, groin, joints, feet)

• Previous treatment of the burn wound

• Previous burn injury to the same area, electrical burn, and patients with inhalation injury

• Patients with diabetes, known sensitivity or allergy to one of the dressings or their constituents and allergy to NSAIDS

• Those being treated with systematic steroid medication

• Patients with AIDS and AIDS related complex