A Test of Neural Inertia in Humans With Xenon

• Status: Active, not recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The dual objectives of this study are to determine if the phenomenon of neural inertia is present in humans and to determine whether the order of neurocognitive function is invariant among anesthetic agents. This study will enroll 24 healthy volunteers, ages 20-40 years, who will receive xenon gas (concentrations ranging from 0% to 60%) delivered via inhaled route through the ENHANCER 3000.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pennsylvania
• Treatments: Xenon

Criteria

Inclusion Criteria:

• Healthy volunteers ages 20-40 years old

• American Society of Anesthesiologists (ASA) Physical Status I or II (i.e. healthy)

• Body Mass Index <30 kg/m2

• Easily visible uvula

Exclusion Criteria:

• Any physical signs that would suggest a difficult airway (e.g. mouth opening <3cm, short distance between the chin and neck, poor mandibular subluxation, thick neck)

• History of reactive airway disease

• Current or history of neuropsychiatric disorders

• History or current use of psychotropic medications,

• History or current obstructive sleep apnea

• Current or history of cardiovascular disease or arrhythmias,

• Current or history of chronic sleep disorders

• History of postoperative nausea/vomiting

• Family history of problems with anesthesia (including but not limited to malignant hyperthermia),

• Current or history of Motion sickness

• Current tobacco use

• Current pregnancy or currently breastfeeding

• Positive urine toxicology screen

• History of seizure disorder, head injury, or brain tumor

• Alcohol consumption greater than 12 drinks per week or more than 4 drinks on any single day

• Inability to provide informed consent

• Inability to achieve mask seal on intervention day